Sex and steriods

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To describe the impact of supra-physiologic anabolic-androgenic steroid AAS use, including agent, dosage, and duration of therapy, on sexual function. The online survey consisted of questions addressing demographics, anabolic steroid use and patterns, ancillary medications, testosterone T -related symptoms while on and off of therapy, as well as sexual function which was assessed using the 5-item, International Index of Erectile Function IIEF A total of men responded to the survey, of which 90 failed to meet inclusion criteria, for a final cohort of AAS users.

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Steroids - From Physiology to Clinical Medicine. Sex steroids are crucial hormones for the proper development and function of the body; they regulate sexual differentiation, the secondary sex characteristics, and sexual behavior patterns. Sex hormones production is sexually dimorphic, and involves differences not only in hormonal action but also in regulation and temporal patterns of production.

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For several decades, exogenous steroid hormones have been explored by researchers and pet owners alike to contracept dogs and cats. Administered in either injectable or oral forms, they cause hormonal down-regulation and can suppress fertility with consistent use. They can work via a variety of mechanisms, including suppression of GnRH through negative feedback at the level of the brain or pituitary gland, or by direct effects on the uterus females or sperm transport males.

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Sex steroidsalso known as gonadocorticoids and gonadal steroidsare steroid hormones that interact with vertebrate androgen or estrogen receptors. The polypeptide hormones luteinizing hormonefollicle-stimulating hormone and gonadotropin-releasing hormone are usually not regarded as sex hormones, although they play major sex-related roles. Natural sex steroids are made by the gonads ovaries or testes[3] by adrenal glandsor by conversion from other sex steroids in other tissue such as liver or fat.

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Historically, the effects of gender have been largely ignored across biomedical research. Subsequent to this practice, studies utilizing immortalized cell lines, single-sex animal models or human patients representing only one sex have resulted in the inability to determine whether research findings are applicable to both sexes Johnson et al. In recent years, concerns initially raised about the lack of women in clinical studies Kim et al.

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Please take this quick survey to tell us about what happens after you publish a paper. Fish Physiology and Biochemistry. Studies of the in vitro gonadal steroidogenesis in intersexual fishes, using labelled testosterone as precursor, showed large species variation.

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All androgens and estrogens in post-menopausal women are synthesized locally in peripheral target tissues by tissue-specific steroidogenic enzymes according to the intracrine process. The importance of the intracrine or peripheral formation of sex steroids is illustrated by the success of aromatase inhibitors and antiestrogens in the prevention and treatment of breast cancer in post-menopausal women. On the other hand, a large series of problems are associated with the deficiency of sex steroids accompanying menopause and the decreased secretion of DHEA, osteoporosis being the best defined example.

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Neurosteroids View all 38 Articles. Sex steroids play essential roles in the modulation of synaptic plasticity and neuroprotection in the hippocampus. Accumulating evidence shows that hippocampal neurons synthesize both estrogen and androgen.

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Estrogens and androgens influence the growth and maintenance of bones and muscles and are responsible for their sexual dimorphism. A decline in their circulating levels leads to loss of mass and functional integrity in both tissues. In the article, we highlight the similarities of the molecular and cellular mechanisms of action of sex steroids in the two tissues; the commonality of a critical role of mechanical forces on tissue mass and function; emerging evidence for an interplay between mechanical forces and hormonal and growth factor signals in both bones and muscles; as well as the current state of evidence for or against a cross-talk between muscles and bone. In addition, we review evidence for the parallels in the development of osteoporosis and sarcopenia with advancing age and the potential common mechanisms responsible for the age-dependent involution of these two tissues.

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